Apoptosis Maintains Oocyte Quality in Aging Caenorhabditis elegans Females
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Apoptosis Maintains Oocyte Quality in Aging Caenorhabditis elegans Females
In women, oocytes arrest development at the end of prophase of meiosis I and remain quiescent for years. Over time, the quality and quantity of these oocytes decreases, resulting in fewer pregnancies and an increased occurrence of birth defects. We used the nematode Caenorhabditis elegans to study how oocyte quality is regulated during aging. To assay quality, we determine the fraction of oocyt...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2008
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1000295